|
|||||
|
|
Confirmation of the absolute configuration of (−)-aurantioclavine |
|
| Authors: | Douglas C BehennaShyam Krishnan Brian M Stoltz |
| Institution: | a California Institute of Technology, Division of Chemistry and Chemical Engineering, Mail Code 101-20, Pasadena, CA 91125, USA b HHMI Institute, University of California, San Francisco, Genentech Hall, 600 16th St, MC 2280, San Francisco, CA 94158, USA |
| Abstract: | We confirm our previous assignment of the absolute configuration of (−)-aurantioclavine as 7R by crystallographically characterizing an advanced 3-bromoindole intermediate reported in our previous synthesis. This analysis also provides additional support for our model of enantioinduction in the palladium(II)-catalyzed oxidative kinetic resolution of secondary alcohols. |
| Keywords: | Aurantioclavine Absolute configuration Oxidative kinetic resolution Indole alkaloid Azepinoindole |
| 本文献已被 ScienceDirect 等数据库收录！ | |