Rhodium‐Catalyzed Enantioposition‐Selective Hydroarylation of Divinylphosphine Oxides with Aryl Boroxines |
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| Authors: | Dr Zhe Wang Prof?Dr Tamio Hayashi |
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| Institution: | Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, Singapore |
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| Abstract: | The rhodium‐catalyzed hydroarylation of divinylphosphine oxides (RP(O)(CH=CH2)2) with aryl boroxines ((ArBO)3) gives the corresponding monoarylation products (RP(O)(CH=CHAr)CH2CH3) in high yields. One of the two vinyl groups in the phosphine oxide undergoes oxidative arylation while the other one is reduced to an ethyl moiety. These reactions proceed with high selectivity in terms of the enantiotopic vinyl groups in the presence of (R)‐DTBM‐segphos/Rh to give the P‐stereogenic monoarylation products with high enantioselectivity. |
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| Keywords: | asymmetric hydroarylation chiral phosphines desymmetrization P-stereogenic centers rhodium catalysis |
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