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(Radio)fluoroclick Reaction Enabled by a Hydrogen‐Bonding Cluster |
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| Authors: | Xiaojun Zeng Dr. Junling Li Dr. Chin K. Ng Dr. Gerald B. Hammond Dr. Bo Xu |
| Affiliation: | 1. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China;2. Department of Diagnostic Radiology, University of Louisville, Louisville, KY, USA;3. Department of Chemistry, University of Louisville, Louisville, KY, USA |
| Abstract: | We have developed a widely applicable nucleophilic (radio)fluoroclick reaction of ynamides with readily available and easy‐to‐handle KF(18F). The reactions exhibited high functional‐group tolerance and needed only an ambient atmosphere. This 18F addition to C?C unsaturated bonds proceeded with extraordinarily high radiochemical yields. |
| Keywords: | alkali fluorides fluorination hydrogen bonds radiofluorination ynamides |