Interfacial Nanoprecipitation toward Stable and Responsive Microbubbles and Their Use as a Resuscitative Fluid |
| |
| Authors: | Dr. Yifeng Peng Dr. Raymond P. Seekell Alexis R. Cole Jemima R. Lamothe Andrew T. Lock Sarah van den Bosch Xiaoqi Tang Prof. Dr. John N. Kheir Prof. Dr. Brian D. Polizzotti |
| |
| Affiliation: | 1. Translational Research Laboratory, Department of Cardiology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA;2. Translational Research Laboratory, Department of Cardiology, Boston Children's Hospital, Boston, MA, USA |
| |
| Abstract: | A new approach has been developed to prepare stable microbubbles (MBs) by interfacial nanoprecipitation of bioabsorbable polymers at air/liquid interfaces. This facile method offers robust control over the morphology and chemophysical properties of MBs by simple chemical modifications. This approach is amenable to large‐scale manufacturing, and is useful to develop functional MBs for advanced biomedical applications. To demonstrate this, a MB‐based intravenous oxygen carrier was created that undergoes pH‐triggered self‐elimination. Intravenous injection of previous MBs increased the risk of pulmonary vascular obstruction. However, we show, for the first time, that our current design is superior, as they 1) yielded no evidence of acute risks in rodents, and 2) improved the survival in a disease model of asphyxial cardiac arrest (from 0 to 100 %), a condition that affects more than 100 000 in‐hospital patients, and carries a mortality of about 90 %. |
| |
| Keywords: | biocompatible polymers cardiac arrest microbubbles nanoprecipitation oxygen delivery |
|
|
