Highly Fluorescent Chiral N‐S‐Doped Carbon Dots from Cysteine: Affecting Cellular Energy Metabolism |
| |
| Authors: | Dr Feng Li Dr Yiye Li Dr Xiao Yang Xuexiang Han Yang Jiao Prof Taotao Wei Prof Dayong Yang Prof Huaping Xu Prof Guangjun Nie |
| |
| Institution: | 1. Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing, P. R. China;2. School of Chemical Engineering and Technology, Key Laboratory of Systems Bioengineering (Ministry of Education), Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin, P. R. China;3. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center of Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, P. R. China;4. University of Chinese Academy of Sciences, Beijing, P. R. China;5. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, P. R. China |
| |
| Abstract: | Cysteine‐based chiral optically active carbon dots (CDs) and their effects on cellular energy metabolism, which is vital for essential cellular functions, have been barely reported. A green and effective synthesis strategy for chiral N‐S‐doped CDs (fluorescence quantum yield ca. 41.26 %) based on hydrothermal treatment of l ‐ or d ‐cysteine at as low as 60 °C has been developed. This suggested that cysteine was instable in aqueous solutions and acts as a warning for high‐temperature synthesis of nanomaterials using cysteine as stabilizer. Human bladder cancer T24 cells treated with l ‐CDs showed up‐regulated glycolysis, while d ‐CDs had no similar effects. In contrast, no disturbance to the basal mitochondrial aerobic respiration of T24 cells was caused by either chiral CD. |
| |
| Keywords: | carbon dots cellular energy metabolism chirality glycolysis green synthesis |
|
|
