Total Synthesis of Bryostatin 8 Using an Organosilane‐Based Strategy |
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| Authors: | Yuebao Zhang Qianyou Guo Xianwei Sun Ji Lu Yanjun Cao Qiang Pu Zhiwen Chu Dr. Lu Gao Prof. Dr. Zhenlei Song |
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| Affiliation: | 1. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, China;2. State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin, China |
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| Abstract: | Convergent total synthesis of bryostatin 8 has been accomplished by an organosilane‐based strategy. The C ring is constructed stereoselectively through a geminal bis(silane)‐based [1,5]‐Brook rearrangement, and the B ring through geminal bis(silane)‐based Prins cyclization, thus efficiently joining the northern and southern parts of the molecule. |
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| Keywords: | cyclization natural products pyrans rearrangements total synthesis |
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