Palladium‐Catalyzed Regioselective Aromatic Extension of Internal Alkynes through a Norbornene‐Controlled Reaction Sequence |
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Authors: | Dr. Qingyang Zhao Dr. Wai Chung Fu Prof. Dr. Fuk Yee Kwong |
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Affiliation: | 1. Department of Chemistry, The Chinese University of Hong Kong, New Territories, Hong Kong, Hong Kong;2. Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, China |
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Abstract: | A regioselective aromatic π‐extension reaction of internal alkynes is reported. The proposed method employs three easily available components, namely aryl halides, 2‐haloarylcarboxylic acids, and disubstituted acetylenes. The transformation is driven by a controlled reaction sequence of C?H activation, decarboxylation, and annulation to give poly(hetero)aromatic compounds in a site‐selective fashion. Unlike in previously reported palladium‐catalyzed three‐component annulations, alkyne carbopalladation is the last step of this tandem reaction. |
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Keywords: | annulation C− H activation decarboxylation multicomponent reactions palladium |
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