Palladium‐Catalyzed Regioselective Aromatic Extension of Internal Alkynes through a Norbornene‐Controlled Reaction Sequence |
| |
| Authors: | Dr. Qingyang Zhao Dr. Wai Chung Fu Prof. Dr. Fuk Yee Kwong |
| |
| Affiliation: | 1. Department of Chemistry, The Chinese University of Hong Kong, New Territories, Hong Kong, Hong Kong;2. Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, China |
| |
| Abstract: | A regioselective aromatic π‐extension reaction of internal alkynes is reported. The proposed method employs three easily available components, namely aryl halides, 2‐haloarylcarboxylic acids, and disubstituted acetylenes. The transformation is driven by a controlled reaction sequence of C?H activation, decarboxylation, and annulation to give poly(hetero)aromatic compounds in a site‐selective fashion. Unlike in previously reported palladium‐catalyzed three‐component annulations, alkyne carbopalladation is the last step of this tandem reaction. |
| |
| Keywords: | annulation C− H activation decarboxylation multicomponent reactions palladium |
|
|
