Diversity‐Oriented Synthesis of Furo[3,2‐c]coumarins and Benzofuranyl Chromenones through Chemoselective Acylation/Wittig Reaction |
| |
Authors: | Chun‐Kai Lin Dr. Praneeth Karanam Dr. Ganapuram Madhusudhan Reddy Dr. Yi‐Ling Tsai Prof. Dr. Wenwei Lin |
| |
Affiliation: | Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan, R.O.C. |
| |
Abstract: | A highly efficient and chemoselective one‐pot protocol for the diversity‐oriented synthesis of two types of coumarin‐based formal cross‐coupling adducts, furo[3,2‐c]coumarins and 3‐benzofuranyl chromenones, is described. Key attributes of the methodology are an initial chemoselective acylation of functionalized phosphorus zwitterions and a subsequent chemoselective intramolecular Wittig reaction that preferentially resulted in one of the two coumarin derivatives in high yield, depending on relative reactivities and the addition sequence of the acylating agents. |
| |
Keywords: | chemoselectivity diversity-oriented synthesis multicomponent reactions organophosphonium salts Wittig reactions |
|
|