Lewis Acid Catalyzed Stereoselective Dearomative Coupling of Indolylboron Ate Complexes with Donor–Acceptor Cyclopropanes and Alkyl Halides |
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| Authors: | Saikat Das Dr Constantin G Daniliuc Prof Dr Armido Studer |
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| Institution: | NRW Graduate School of Chemistry, Organisch-Chemisches Institut, Westf?lische Wilhelms-Universit?t, Münster, Germany |
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| Abstract: | Indolylboron ate complexes readily generated from 2‐lithioindoles and boronic esters underwent multicomponent dearomative coupling with D‐A cyclopropanes and alkyl halides in the presence of Sc(OTf)3 as a catalyst. The reactions proceeded with complete diastereoselectivity and excellent stereospecificity to provide indolines containing three contiguous stereocenters. The valuable boronic ester moiety remains in the product and allows for subsequent functionalization. |
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| Keywords: | boron donor– acceptor cyclopropanes multicomponent reactions ring-opening reactions stereospecificity |
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