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Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near‐Infrared Window Emission
Authors:Ge Xu  Qinglong Yan  Xiaoguang Lv  Prof Ying Zhu  Kai Xin  Ben Shi  Rongchen Wang  Jian Chen  Wei Gao  Prof Ping Shi  Prof Chunhai Fan  Prof Chunchang Zhao  Prof He Tian
Institution:1. Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, P. R. China;2. Division of Physical Biology & Bioimaging Center, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, P. R. China;3. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, P. R. China
Abstract:Fluorescent probes in the second near‐infrared window (NIR‐II) allow high‐resolution bioimaging with deep‐tissue penetration. However, existing NIR‐II materials often have poor signal‐to‐background ratios because of the lack of target specificity. Herein, an activatable NIR‐II nanoprobe for visualizing colorectal cancers was devised. This designed probe displays H2S‐activated ratiometric fluorescence and light‐up NIR‐II emission at 900–1300 nm. By using this activatable and target specific probe for deep‐tissue imaging of H2S‐rich colon cancer cells, accurate identification of colorectal tumors in animal models were performed. It is anticipated that the development of activatable NIR‐II probes will find widespread applications in biological and clinical systems.
Keywords:colon cancer  fluorescence  in   vivo imaging  nanoprobes  second near-infrared window
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