Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near‐Infrared Window Emission |
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| Authors: | Ge Xu Qinglong Yan Xiaoguang Lv Prof Ying Zhu Kai Xin Ben Shi Rongchen Wang Jian Chen Wei Gao Prof Ping Shi Prof Chunhai Fan Prof Chunchang Zhao Prof He Tian |
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| Institution: | 1. Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, P. R. China;2. Division of Physical Biology & Bioimaging Center, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, P. R. China;3. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, P. R. China |
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| Abstract: | Fluorescent probes in the second near‐infrared window (NIR‐II) allow high‐resolution bioimaging with deep‐tissue penetration. However, existing NIR‐II materials often have poor signal‐to‐background ratios because of the lack of target specificity. Herein, an activatable NIR‐II nanoprobe for visualizing colorectal cancers was devised. This designed probe displays H2S‐activated ratiometric fluorescence and light‐up NIR‐II emission at 900–1300 nm. By using this activatable and target specific probe for deep‐tissue imaging of H2S‐rich colon cancer cells, accurate identification of colorectal tumors in animal models were performed. It is anticipated that the development of activatable NIR‐II probes will find widespread applications in biological and clinical systems. |
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| Keywords: | colon cancer fluorescence in vivo imaging nanoprobes second near-infrared window |
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