Regulating Higher‐Order Organization through the Synergy of Two Self‐Sorted Assemblies |
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Authors: | Dr Wei Ji Shijin Zhang Sachie Yukawa Shogo Onomura Toshio Sasaki Kun'ichi Miyazawa Prof?Dr Ye Zhang |
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Institution: | 1. Bioinspired Soft Matter Unit, Okinawa Institute of Science and Technology Graduate University, Onna-son, Okinawa, Japan;2. Shimadzu Techno-Research Co. Ltd., Kyoto, Japan;3. Imaging Section, Okinawa Institute of Science and Technology Graduate School, Japan |
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Abstract: | The extracellular matrix (ECM) is the natural fibrous scaffold that regulates cell behavior in a hierarchical manner. By mimicking the dynamic and reciprocal interactions between ECM and cells, higher‐order molecular self‐assembly (SA), mediated through the dynamic growth of scaffold‐like nanostructures assembled by different molecular components, was developed. Designed and synthesized were two self‐sorted coumarin‐based gelators, a peptide molecule and a benzoate molecule, which self‐assemble into nanofibers and nanobelts, respectively, with different dynamic profiles. Upon the dynamic growth of the fibrous scaffold assembled from peptide gelators, nanobelts assembled from benzoate gelators transform into a layer‐by‐layer nanosheet, reaching ninefold increase in height. By using light and an enzyme, the spatial–temporal growth of the scaffold can be modified, leading to in situ height regulation of the higher‐order architecture. |
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Keywords: | coumarin gelators higher-order organization self-assembly self-sorting |
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