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Enantioselective Desymmetrization of Cyclobutanones Enabled by Synergistic Palladium/Enamine Catalysis |
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| Authors: | Meng Wang Jun Chen Zongjia Chen Changxu Zhong Prof Dr Ping Lu |
| Institution: | 1. http://rcmrs.fudan.edu.cn/Data/View/173
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| Abstract: | The enantioselective intramolecular α‐arylation of cyclobutanones has been established by combining palladium and enamine catalyst systems. Two different enantioselective control strategies have been developed for cyclobutanone substrates bearing O‐ or N‐tethered aryl bromides. Further synthetic applications are also reported. |
| Keywords: | arylation cyclobutanones desymmetrization palladium synergistic catalysis |