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Multimodal investigations of trans-endothelial cell trafficking under condition of disrupted blood-brain barrier integrity |
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| Authors: | Nicola Marchi Qingshan Teng Minh T Nguyen Linda Franic Nirav K Desai Thomas Masaryk Peter Rasmussen Silvia Trasciatti and Damir Janigro |
| Institution: | (1) Department of Cerebrovascular Research Cell Biology, Cleveland Clinic Lerner College of Medicine, 9500 Euclid Ave, Cleveland, 44106, Ohio, USA;(2) Departments of Neurosurgery, Cleveland Clinic Lerner College of Medicine, 9500 Euclid Ave, Cleveland, 44106, Ohio, USA;(3) Neuroradiology, Cleveland Clinic Lerner College of Medicine, 9500 Euclid Ave, Cleveland, 44106, Ohio, USA;(4) AbiogenPharma Spa, Pisa, 57100, Italy |
| Abstract: | BackgroundStem cells or immune cells targeting the central nervous system (CNS) bear significant promises for patients affected by CNS disorders. Brain or spinal cord delivery of therapeutic cells is limited by the blood-brain barrier (BBB) which remains one of the recognized rate-limiting steps. Osmotic BBB disruption (BBBD) has been shown to improve small molecule chemotherapy for brain tumors, but successful delivery of cells in conjunction with BBBD has never been reported. |
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