| Synthesis,Crystal Structure and Antitumor Activity of a New Coordination Polymer [Cd（C（14）H（10）N3O5）2（C5H5N）2]n |
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| 作者姓名： | QIU Xiao-Yang ZHU Mei-An ZHANG Ming-Wei XU Mao-Tian ZHU Hai-Liang |
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| 作者单位： | QIU Xiao-Yang(State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing 210093,China ;Department of Chemistry,Shangqiu Normal University,Shangqiu 476000,China);ZHU Mei-An(Department of Chemistry,Fuyang Normal University,Fuyang 236000,China);ZHANG Ming-Wei,XU Mao-Tian(Department of Chemistry,Shangqiu Normal University,Shangqiu 476000,China);ZHU Hai-Liang(State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing 210093,China) |
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| 基金项目： | The work was supported by the NNSFC （20775047） and the Education Office of Henan and Anhui Provinces （2009A150020 and KJ2008B 178） |
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| 摘 要： | A new cadmium coordination polymer,Cd(C14H10N3O5)2(C5H5N)2]n,has been synthesized by the reaction of 2-hydroxy-N'-(4-nitrobenzoyl)benzohydraizide with cadmium acetate in pyridine and ethanol mixture solution.Its molecular structure was characterized by elemental analysis,IR spectra and X-ray crystal structure determination.Crystal data for this compound:tetragonal,space group I41/a,Mr=871.10,a=16.960(6),b=16.960(6),c=28.612(6) ,V= 8230(4)3,Z=8,Dc=1.406 g·m-3 and F(000)=3536.the final R=0.0326,wR=0.0847 for 2682 observed reflections with I 2σ(I) and R=0.0460,wR=0.0896 for all reflections.In the molecular structure of the complex,the cadmium atoms are coordinated to four N and two O atoms forming a slightly distorted octahedral geometry.The intermolecular hydrogen bonds link the neighboring molecules to form a coordination polymer which was then evaluated for its anti-tumor activities against two kinds of cell lines (K562 and BGC) by MTT method.A preliminary bioactivity study indicates that the complex has distinct inhibitory effect on K562 cell lines.
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| 关 键 词： | 镉配位聚合物 抗肿瘤活性 晶体结构 吡啶 合成 K562细胞 分子结构 分子间氢键 |
Synthesis, Crystal Structure and Antitumor Activity of a New Coordination Polymer[Cd(C14H10N3O5)2(C5H5N)2]n |
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| QIU Xiao-Yang,ZHU Mei-An,ZHANG Ming-Wei,XU Mao-Tian,ZHU Hai-Liang.Synthesis, Crystal Structure and Antitumor Activity of a New Coordination Polymer[Cd(C14H10N3O5)2(C5H5N)2]n[J].Chinese Journal of Structural Chemistry,2010,29(5):806-810. |
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| Authors: | QIU Xiao-Yang ZHU Mei-An ZHANG Ming-Wei XU Mao-Tian ZHU Hai-Liang |
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| Abstract: | A new cadmium coordination polymer, Cd(C14H10N3O5)2(C5H5N)2]n,has been synthesized by the reaction of 2-hydroxy-N'-(4-nitrobenzoyl)benzohydraizide with cadmium acetate in pyridine and ethanol mixture solution. Its molecular structure was characterized by elemental analysis, IR spectra and X-ray crystal structure determination. Crystal data for this compound:tetragonal, space group I41/α, Mr = 871.10, a = 16.960(6), b = 16.960(6), c = 28.612(6) (A), V =observed reflections with Ⅰ＞ 2σ(Ⅰ) and R = 0.0460, wR = 0.0896 for all reflections. In the molecular structure of the complex, the cadmium atoms are coordinated to four N and two O atoms forming a slightly distorted octahedral geometry. The inter-molecular hydrogen bonds rink the neighboring molecules to form a coordination polymer which was then evaluated for its anti-tumor activities against two kinds of cell lines (K562 and BGC) by MTT method. A preliminary bioactivity study indicates that the complex has distinct inhibitory effect on K.562 cell lines. |
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| Keywords: | crystal structure anti-tumor activity |
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