ICP-AES法测定蒙药紫癜灵中多种微量元素

蒙药含有多种氨基酸和丰富的微量元素，特别是人体必需的微量元素含量相对较高，而对人体有害的重金属元素含量相对较低。采用微波消解ICP-AES法同时测定了治疗过敏性紫癜的蒙药紫癜灵中Ca, Mg, Sr, Fe, Mn, Zn, Cu和Pb等15种微量元素。紫癜灵的临床药效实验，选择了过敏性紫癜患者260例，其中男性140例，女性120例；年龄最小6岁，最大62岁，6～16岁年龄段最多，占病人总数的90%左右。治疗结果显示：治愈234例，占90%；显效13例，占5%；有效11例，占4.23%；无效2例，占0.77%；总有效率达99.23%。紫癜灵中含有丰富的微量元素，尤其锶的含量相当高。方法的加标回收率在94.63%～106.40% 之间，相对标准偏差RSD≤3.17%，检出限≤0.009 μg·L-1。

Determination of Trace Elements in Mongolian Medicine Zidianling Curing Allergic Purpura Disease by ICP-AES

During the study of the Mongolian medicine Zidianling, the authors found that the Mongolian medicine Zidianling contains great amount of trace elements in which human-body-needed trace elements are fairly much but the heavy metals are very little. A method using ICP-AES with microwave digestion was studied for the determination of 15 elements including Ca, Mg, Sr, Fe, Mn, Zn, Cu, Pb, etc. in Mongolian medicine-Zidianling. The major function of this medicine is clearing away heat and removing toxic substances, and cooling blood to stop bleeding. To explain the Zidianling’s clinical effects, the authors chose 260 allergic purpura patients with 140 male and 120 female. The youngest was 6 years old, the oldest was 62 years old. Most of patients were between 6 and 16, accounting for nearly 90%. The results of clinical effects show that 234 patients were cured, roughly 90% of the total number Thirteen patients showed obvious effects (5% of the total number) and 11 had effective cures of illnesses (4.23% of the total number). Two patients had no cures of illnesses (0.77% of the total number). And the integrated effective rate may reach 99.23%. The results show that Mongolian medicine Zidianling has great amount of trace elements and its Sr content is different from other Mongolian medicines and is especially high. The recoveries of standard addition are in the range of 94.63%-106.40%. The relative standard deviation RSD≤3.17%, and the detection limit is in the range of ≤0.009 μg·mL-1.