A novel heptacyclic diterpene from Alpinia pahangensis Ridley,a wild ginger endemic to Malaysia |
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| Institution: | 1. Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia;2. Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia;3. Integrative Pharmacogenomics Institute, Universiti Teknologi MARA, 42300 Bandar Puncak Alam, Selangor, Malaysia;4. Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia;1. Dipartimento di Chimica, Università degli Studi di Pavia, Viale Taramelli 12, 27100 Pavia, Italy;2. Centro Grandi Strumenti, Università degli Studi di Pavia, Via Bassi 21, 27100 Pavia, Italy;1. The Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 32322, United States;2. Department of Hepatobiliary Surgery, NanFang Hospital, Guangzhou, People''s Republic of China;3. Department of Gastroenterology, NanFang Hospital, Guangzhou, People''s Republic of China;4. Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People''s Republic of China;1. Faculty of Materials Science and Applied Chemistry, Institute of Technology of Organic Chemistry, Riga Technical University, P. Valdena Str. 3, Riga LV-1048, Latvia;2. Latvian Institute of Organic Synthesis, 21 Aizkraukles Str, Riga LV-1006, Latvia;3. Department of Chemistry, Josip Juraj Strossmayer University of Osijek, Cara Hadrijana 8/A, 31000 Osijek, Croatia;1. Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan;2. Department of Biotechnology, Hungkuang University, Taichung 443, Taiwan;3. Department of Nursing, Hungkuang University, Taichung 443, Taiwan;4. Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan;5. Agricultural Biotechnology Center, National Chung-Hsing University, Taichung 402, Taiwan;6. Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan;7. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan;8. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan;9. Department of Cosmeceutics, China Medical University, Taichung 404, Taiwan;10. Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan;11. Department of Chemistry, National Taiwan University, Taipei 106, Taiwan;12. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan;13. Department of Biotechnology, Asia University, Taichung 413, Taiwan;1. College of Pharmacy, Harbin Medical University, No. 157 Baojian Road, Nangang District, Harbin 150081, China;2. Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, New Brunswick, NJ 08854, USA;3. Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, China;4. Department of Pharmacy, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China |
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| Abstract: | Pahangensin D (1), a bis-labdanic diterpene featuring an unprecedented carbon skeleton, was isolated as a minor constituent from the rhizomes of Alpinia pahangensis Ridley. Its structure and relative stereochemistry were established on the basis of rigorous spectroscopic methods including 1D and 2D NMR techniques and LCMS-IT-TOF analysis. |
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| Keywords: | Zingiberaceae Bis-labdanic diterpenes Pahangensin D |
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