首页 | 本学科首页   官方微博 | 高级检索  
     


Design of new synthetic strategies to cyclophanes via ring-closing metathesis
Affiliation:1. Screening Laboratory, Institute of Medical Biology, Polish Academy of Sciences, 106 Lodowa St., Lodz 93-232, Poland;2. Laboratory of Molecular Virology and Biological Chemistry, Institute of Medical Biology, Polish Academy of Sciences, 106 Lodowa St., Lodz 93-232, Poland;3. Institute of Bioorganic Chemistry, Polish Academy of Sciences, Laboratory of RNA Chemistry, 12/14 Noskowskiego, Poznan 61-704, Poland;4. Thomas Jefferson University, Department of Biochemistry and Molecular Biology, Laboratory of Nucleic Acid Therapeutics, 233 S. 10th Street, Philadelphia, PA 19107-5541, USA;1. N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prosp., 119991 Moscow, Russian Federation;2. A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov St., 119991 Moscow, Russian Federation;1. School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China;2. Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, 20018 San Sebastián, Spain;3. Japan Synchrotron Radiation Research Institute, SPring-8, 1-1-1 Kouto, Sayo-gun, 679-5198 Sayo-cho, Hyogo, Japan;4. Department of Chemistry and Materials Science, Tokyo Institute of Technology, Ookayama 2, Meguro-ku, Tokyo 152-8551, Japan;5. National Institute of Advanced Industrial Science and Technology (AIST), Anagahora 2266-98, Shimoshidami, Moriyama, 463-8560 Nagoya, Aichi, Japan;6. IKERBASQUE, Basque Foundation for Science, María Díaz de Haro 3, 48013 Bilbao, Spain;7. Department of Chemistry, University of Turku, Vatselankatu 2, FIN-20014 Turku, Finland;8. Molecular Structure Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69009 Heidelberg, Germany
Abstract:A simple synthetic methodology to cyclophanes containing hydroxyl groups has been reported. The key steps involved here are: Grignard reaction, double Claisen rearrangement, and ring-closing metathesis. The strategy reported here is protecting group-free synthesis.
Keywords:Cyclophanes  Macrocycles  Ring-closing metathesis  Grignard reaction  Claisen rearrangement  Pyridine derivatives
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号