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A facile synthesis of novel tricyclic 4-pyridones
Affiliation:1. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China;2. Roche Innovation Center Shanghai, 720 Cailun Road, Building 5, Pudong Shanghai 201203, China;1. Department of Biomolecular Science, Section of Organic Chemistry and Organic Natural Compounds, Università degli Studi di Urbino “Carlo Bo”, Via I Maggetti 24, 61029 Urbino, Italy;2. Department of Chemistry, Università degli Studi di Siena, Via Aldo Moro, 53100 Siena, Italy;1. Institute for Advanced Materials, South China Academy of Advanced Optoelectronics, South China Normal University Guangzhou, China;2. Group Linear Conjugated Systems, CNRS, Moltech-Anjou, University of Angers, 2 Bd Lavoisier, 49045, Angers, France;3. Center for Organic Electronics and Alternative Energies, Department of Chemistry, University of Ubon Ratchathani, 34190, Thailand
Abstract:A new and efficient synthesis of tricyclic 4-pyridone analogs through the intramolecular Heck coupling cyclization was described. This reaction features mild conditions and good functional group tolerance allowing for the preparation of several novel tricyclic 4-pyridone analogs.
Keywords:4-Pyridone  Tricyclic  Intramolecular Heck coupling  Palladium bromide
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