A convenient hydroiodination of alkynes using I2/PPh3/H2O and its application to the one-pot synthesis of trisubstituted alkenes via iodoalkenes using Pd-catalyzed cross-coupling reactions |
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| Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People''s Republic of China;2. University of the Chinese Academy of Sciences, Beijing 100049, People''s Republic of China |
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| Abstract: | A facile hydroiodination of alkynes using readily-available reagents such as I2, PPh3, and H2O has been developed. This is extended to the one-pot synthesis of trisubstituted alkenes from alkynes via iodoalkenes using Pd-catalyzed cross-coupling and related methods such as the Suzuki–Miyaura cross-coupling, Sonogashira cross-coupling reaction, and Mizoroki–Heck reaction. |
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| Keywords: | Hydroiodination Cross-coupling reactions Trisubstituted alkenes Phosphorus reagents One-pot synthesis |
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