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A concise Pd catalyzed cross coupling reaction along with deprotection for the synthesis of a new series of pyrimidine derivatives |
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| Affiliation: | 1. Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ 85721, United States;2. College of Pharmacy, University of Oklahoma Health Science Center, Oklahoma City, OK 73117, United States;1. Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene Street, Baltimore, MD 21201, USA;2. Department of Chemistry and Biochemistry, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA;1. Crop Protection Chemicals, Indian Institute of Chemical Technology, Hyderabad 500 007, India;2. Natural Product Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| Abstract: | A new series of 2-amino, 4-azepanone, 5-aryl substituted derivatives of pyrimidine compounds were synthesized for the first time from the commercially available 2-amino-4-hydroxypyrimidine. The key step in the reaction is a conceptually new single step palladium catalyzed cross coupling along with the deprotection of N,N-diisopropylformimidamide using bis(triphenylphosphine)palladium(II) dichloride (PdCl2(PPh3)2). |
| Keywords: | 2-Amino-4-hydroxy pyrimidine 3-Aminoazepan-2-one Bis(triphenylphosphine)palladium(II) dichloride Pd catalyzed deprotection Cross coupling reaction |
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