Two novel abietane dimers from transformed root cultures of Salvia broussonetii |
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| Institution: | 1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People''s Republic of China;2. State Key Laboratory of Phytochemistry and Plant Resourcese in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, People''s Republic of China;3. School of Pharmacy, Dali University, Dali 671003, People''s Republic of China;4. Central Hospital of Wuhan Affiliated to Tongji Medical College, Huazhong University of Science and Technologynd Technology, Wuhan 430000, People''s Republic of China;1. Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;2. Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;3. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;4. Department of Pharmacognosy, University of Szeged, Szeged, Hungary |
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| Abstract: | Broussonetone A (1) and broussonetone B (2), two novel dimeric abietane diterpenes, have been isolated from Salvia broussonetii root cultures transformed by Agrobacterium rhizogenes. The structure of broussonetone A was determined from spectroscopic data and confirmed by X-ray analysis. This dimer can be formed by a 4+2]-cycloaddition of two molecules of 13β-hydroxyabieta-8(14),9(11)-dien-12-one. NMR data of broussonetone B indicated that the C-20 methyl in part B of the broussonetone A molecule had been substituted by an aldehyde group. Thus, broussonetone B could be formed by an analogous Diels Alder reaction between 13β-hydroxyabieta-8(14),9(11)-dien-12-one as the dienophile and its 20-oxo derivative as the electrophile. |
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| Keywords: | Transformed root cultures Diterpene dimers Abietane Broussonetone A Broussonetone B |
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