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Synthesis of new fluorescently labeled glycosylphosphatidylinositol (GPI) anchors |
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| Authors: | Varma SaikamRiya Raghupathy Mahipal YadavVeeranjaneyulu Gannedi Parvinder Pal SinghNaveed A. Qazi Sanghapal D. SawantRam A. Vishwakarma |
| Affiliation: | a Medicinal Chemistry Division, Indian Institute of Integrative Medicine, Council of Scientific and Industrial Research, Jammu 180 001, India b National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560 065, India |
| Abstract: | The borondipyrromethene (BODIPY) labeled new glycosylphosphatidylinositol (GPI) molecules were synthesized as cellular probes to study the chemical basis of microdomain organization of GPI-anchored proteins and cholesterol in plasma membrane. The synthesis enabled by a new stereo-selective glycosylation of myo-d-inositol acceptor led to the preparation of optically pure glucosaminyl-(1-6)-α-phosphatidyl-myo-d-inositol and its unnatural stereoisomer. |
| Keywords: | Glycosylphosphatidylinositol anchors BODIPY fluorescent probe Membrane micro-domains smallcaps" >d and smallcaps" >l-myo-inositol Unnatural GPI analogs |
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