A comparison study between the saturation-recovery-T1 and CASL MRI methods for quantitative CBF imaging |
| |
| Institution: | 1. Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, USA;2. Diagnostic Radiology Residency Program, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, USA;3. Department of Neurology, University of Minnesota Medical School, Minneapolis, MN, USA;1. Department of Medical Imaging, Tongji Hospital, Tongji University, No. 389, Xincun Road, Putuo District, Shanghai 200065, China;2. Department of Medical Imaging, Renji Hospital, Medical School of Jiaotong University, No. 160, Pujian Road, Pudong District, Shanghai 200127, China;1. Department of Radiology, University of Cambridge, United Kingdom;2. GE Healthcare, Amersham, United Kingdom;3. GE Healthcare, Waukesha, WI, USA;4. Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, United Kingdom;1. Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232, USA;2. Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232, USA;3. Department of Physics and Astronomy, Vanderbilt University, Nashville, TN 37232, USA;4. AstraZeneca, Alderley Park, MACCLESFIELD, Cheshire SK10 4TG, United Kingdom;5. Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37232, USA;6. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA;7. Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA;1. Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran;2. School of Cognitive Sciences, Institute for Research in Fundamental Sciences, 1954851167, Tehran, Iran;1. Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland;2. Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland;1. Dept of Radiology, University of Cambridge and Addenbrooke''s Hospital, Hills Rd, CB20QQ, England, United Kingdom;2. GE Healthcare, Amersham, HP7 9NA, United Kingdom |
| |
| Abstract: | The saturation-recovery (SR)-T1 MRI method for quantitatively imaging cerebral blood flow (CBF) change (ΔCBF) concurrently with the blood oxygenation level dependence (BOLD) alteration has been recently developed and validated by simultaneous measurement of relative CBF change using laser Doppler flowmetry (LDF) in rats at 9.4T. In this study, ΔCBF induced by mildly transient hypercapnia and measured by the SR-T1 MRI method was rigorously compared with an established perfusion MRI method—continuous arterial spin labeling (CASL) approach in normal and preclinical middle cerebral artery occlusion (MCAo) rat models. The results show an excellent agreement between ΔCBF values measured with these two imaging methods. Moreover, the intrinsic longitudinal relaxation rate (R1int) was experimentally determined in vivo in normal rat brains at 9.4T by comparing two independent measures of the apparent longitudinal relaxation rate (R1app) and CBF measured by the CSAL approach across a wide range of perfusion. In turn, the R1int constant can be employed to calculate the CBF value based on the R1app measurement in healthy brain. This comparison study validates the fundamental relationship for linking brain tissue water R1app and cerebral perfusion, demonstrates the feasibility of imaging and quantifying both CBF and its change using the SR-T1 MRI method in vivo. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
