Fast T1 mapping of the brain at high field using Look-Locker and fast imaging |
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| Institution: | 1. Paul C. Lauterbur Research Centre for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China;2. Shenzhen Key Laboratory for MRI, Shenzhen, Guangdong, China;1. Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA;2. Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA;3. Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA;4. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA;5. Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA;1. Department of Orthopaedics, Leiden University Medical Center, The Netherlands;2. Department of Radiology, Leiden University Medical Center, The Netherlands;3. Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, The Netherlands;4. Mathematica institute Leiden University, Leiden University Medical Center, The Netherlands;5. C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, The Netherlands;1. Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, BC V6T 1Z1, Canada;2. Medicine, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada;3. Radiology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada |
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| Abstract: | This study aims to develop and evaluate a new method for fast high resolution T1 mapping of the brain based on the Look-Locker technique. Single-shot turboflash sequence with high temporal acceleration is used to sample the recovery of inverted magnetization. Multi-slice interleaved acquisition within one inversion slab is used to reduce the number of inversion pulses and hence SAR. Accuracy of the proposed method was studied using simulation and validated in phantoms. It was then evaluated in healthy volunteers and stroke patients. In-vivo results were compared to values obtained by inversion recovery fast spin echo (IR-FSE) and literatures. With the new method, T1 values in phantom experiments agreed with reference values with median error < 3%. For in-vivo experiments, a T1 map was acquired in 3.35 s and the T1 maps of the whole brain were acquired in 2 min with two-slice interleaving, with a spatial resolution of 1.1 × 1.1 × 4 mm3. The T1 values obtained were comparable to those measured with IR-FSE and those reported in literatures. These results demonstrated the feasibility of the proposed method for fast T1 mapping of the brain in both healthy volunteers and stroke patients at 3T. |
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