Three-dimensional adiabatic inversion recovery prepared ultrashort echo time cones (3D IR-UTE-Cones) imaging of cortical bone in the hip |
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| Affiliation: | 1. Department of Radiology, University of California, San Diego, CA, United States;2. Applied Science Lab, GE Healthcare, San Diego, CA, United States;3. Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States;1. Division of Mathematical oncology, City of Hope National Medical Center, CA, USA;2. Department of Radiology and Imaging, Fortis Memorial Research Institute, Gurgaon, India;3. Department of Biostatistics and Health Informatics, SGPGIMS, Lucknow, India;4. Department of Neurosurgery, Fortis Memorial Research Institute, Gurgaon, India;5. SRL Diagnostics, Fortis Memorial Research Institute, Gurgaon, India;6. Philips Health System, Philips India Limited, Gurgaon, India;1. Changchun Institute of Applied Chemistry Chinese Academy of Sciences, No. 5625, Renmin Street, Changchun 130022, China;2. University of Chinese Academy of Sciences, No. 19, Yuquan Road 19, Beijing 100049, China;1. Institute of Clinical Physiology, National Council of Research, Pisa, Italy;2. Fondazione G. Monasterio CNR - Regione Toscana, Pisa, Italy;3. Laboratory of Medical Physics and Biotechnologies for Magnetic Resonance, IRCCS Stella Maris Foundation, Pisa, Italy;4. Imago7 Foundation, Pisa, Italy;1. Faculty of Engineering, Department of Electrical Engineering, University of Malaya, Kuala Lumpur, Malaysia;2. Department of Electrical Engineering, COMSATS Institute of Information Technology, Islamabad, Pakistan;3. Department of Computer Science & Engineering, Faculty of Science & Engineering, East West University, Dhaka 1212, Bangladesh;1. Department of Reparative Materials, Institute for Frontier Medical Sciences, Kyoto University, Japan;2. Department of Neurosurgery, Jikei University School of Medicine, Japan;3. Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Japan;4. Hiratsuka Technical Center, Tanaka Kikinzoku Kogyo K.K., Japan;5. Isehara Technical Center, Tanaka Kikinzoku Kogyo K.K., Japan |
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| Abstract: | PurposeWe present three-dimensional adiabatic inversion recovery prepared ultrashort echo time Cones (3D IR-UTE-Cones) imaging of cortical bone in the hip of healthy volunteers using a clinical 3T scanner.MethodsA 3D IR-UTE-Cones sequence, based on a short pulse excitation followed by a 3D Cones trajectory, with a nominal TE of 32 μs, was employed for high contrast morphological imaging of cortical bone in the hip of heathy volunteers. Signals from soft tissues such as muscle and marrow fat were suppressed via adiabatic inversion and signal nulling. T2⁎ value of the cortical bone was also calculated based on 3D IR-UTE-Cones acquisitions with a series of TEs ranging from 0.032 to 0.8 ms. A total of four healthy volunteers were recruited for this study. Average T2⁎ values and the standard deviation for four regions of interests (ROIs) at the greater trochanter, the femoral neck, the femoral head and the lesser trochanter were calculated.ResultsThe 3D IR-UTE-Cones sequence provided efficient suppression of soft tissues with excellent image contrast for cortical bone visualization in all volunteer hips. Exponential single component decay was observed for all ROIs, with averaged T2⁎ values ranging from 0.33 to 0.45 ms, largely consistent with previously reported T2⁎ values of cortical bone in the tibial midshaft.ConclusionsThe 3D IR-UTE-Cones sequence allows in vivo volumetric imaging and quantitative T2⁎ measurement of cortical bone in the hip using a clinical 3T scanner. |
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