Correlation study between intravoxel incoherent motion MRI and dynamic contrast-enhanced MRI in head and neck squamous cell carcinoma: Evaluation in primary tumors and metastatic nodes |
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| Institution: | 1. Medical Physics Laboratory, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy;2. Radiology and Diagnostic Imaging Department, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy;3. Department of Radiotherapy, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy;4. Department of Pathology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy;5. Department of Otolaryngology & Head and Neck Surgery, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy;1. Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran;2. School of Cognitive Sciences, Institute for Research in Fundamental Sciences, 1954851167, Tehran, Iran;1. Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland;2. Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland;1. Dept of Radiology, University of Cambridge and Addenbrooke''s Hospital, Hills Rd, CB20QQ, England, United Kingdom;2. GE Healthcare, Amersham, HP7 9NA, United Kingdom;1. Center for Brain Imaging Science and Technology, Zhejiang University, Hangzhou, China;2. Institute of Neuroscience and Medicine-4, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany;3. MR Collaboration Northeast Asia, Siemens Healthcare, Shanghai, China;4. Department of Electronic Science, Xiamen University, Xiamen, China;5. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, China;6. Department of Imaging Sciences, University of Rochester, Rochester, USA;1. Department of Radiology, University of Cambridge, United Kingdom;2. GE Healthcare, Amersham, United Kingdom;3. GE Healthcare, Waukesha, WI, USA;4. Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, United Kingdom |
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| Abstract: | ObjectiveTo correlate intravoxel incoherent motion (IVIM) imaging and dynamic contrast-enhanced (DCE) MRI in head and neck squamous cell carcinoma (HNSCC).MethodsForty untreated patients with HNSCC were included retrospectively in the study. Perfusion fraction f, diffusion coefficient D and perfusion-related diffusion coefficient D* were extracted by bi-exponential fitting of IVIM data. Semi-quantitative DCE-MRI parameters, including positive enhancement integral (PEI) and maximum slope of increase (MSI), were calculated. The relationships between all variables were assessed by Spearman's test for correlation.Results27 primary tumors (PTs) and 23 lymph nodes (LNs) were analyzed. The residual sum of squares (RSS), used to assess the fit quality, was significantly different between PTs and LNs, with the last showing lower values. In LNs, D* and the product D* × f were positively related to both nPEI and nMSI, while no significant correlation was found in PTs.ConclusionEvident relationships between D* and D* × f and DCE-MRI perfusion measurements were found in LNs, while no significant association emerged in PTs. This presumably is due to the poorer agreement between the experimental data and curve fitting for PTs, as compared to LNs. Additional work is warranted to improve the reliability of the IVIM parameter estimations in primary HNSCCs. |
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