Black-blood T2* mapping with delay alternating with nutation for tailored excitation |
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| Institution: | 1. Paul C Lauterbur Research Centre for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China;2. Centers for Biomedical Engineering, College of Information Science and Technology, University of Science and Technology of China, Hefei, China;3. Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA;4. School of Information Science and Technology, Northwest University, Xian, China;1. Heidelberg University Hospital, Department of Neuroradiology, Heidelberg, Germany;2. German Cancer Research Center, Radiology E010, Heidelberg, Germany;3. Humboldt University Berlin, Department of Physics, Berlin, Germany;4. University Hospital Würzburg, Department of Internal Medicine I, Würzburg, Germany;5. University Hospital Würzburg, Division of Neuroradiology, Würzburg, Germany;6. University of Würzburg, Department of Physics V, Würzburg, Germany;1. Department of Radiology, University of Chicago, Chicago, IL, USA;2. Medicine, Hematology/Oncology, University of Chicago, Chicago, IL, USA;1. Aging Research Center (ARC), Karolinska Institute and Stockholm University, Sweden;2. MRI Research Center, Karolinska University Hospital, Sweden;1. Guangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University, No. 1838, Guangzhou Road North, Guangzhou, China;2. Neusoft Medical System, No. 10001, Ziyue Road, Shanghai, China;3. Philips, Healthcare, No. 33, Zhongshan San Road, Guangzhou, China;4. Philips, Healthcare, No. 258, Zhongyuan Road, Suzhou, China;5. Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, No. 30, Shuangqing Road, Beijing, China;1. Biomedical Engineering, Vanderbilt University, Nashville, TN, USA;2. Vanderbilt University, Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA;3. Computer Science, Vanderbilt University, Nashville, TN, USA;4. Electrical Engineering, Vanderbilt University, Nashville, TN, USA |
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| Abstract: | PurposeTo develop a black-blood T2* mapping method using a Delay Alternating with Nutation for Tailored Excitation (DANTE) preparation combined with a multi-echo gradient echo (GRE) readout (DANTE-GRE).Materials and methodsSimulations of the Bloch equation for DANTE-GRE were performed to optimize sequence parameters. After optimization, the sequence was applied to a phantom scan and to neck and lower extremity scans conducted on 12 volunteers at 3 T using DANTE-GRE, Motion-Sensitized Driven Equilibrium (MSDE)-GRE, and multi-echo GRE. T2* values were measured using an offset model. Statistical analyses were conducted to compare the T2* values between the three sequences.ResultsSimulation results showed that blood suppression can be achieved with various DANTE parameter adjustments. T2* maps acquired by DANTE-GRE were consistent and comparable to those acquired with multi-echo GRE in phantom experiments. In the in vivo experiments, DANTE-GRE was more comparable to multi-echo GRE than MSDE-GRE regarding the measurement of muscle T2* values.ConclusionDue to its high signal intensity retention and effective blood signal suppression, DANTE-GRE allows for robust and accurate T2* quantification, superior to that of MSDE-GRE, while overcoming blood flow artifacts associated with traditional multi-echo GRE. |
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