Assessing the effect of football play on knee articular cartilage using delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) |
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| Institution: | 1. Wright Center of Innovation in Biomedical Imaging, Department of Radiology, The Ohio State University, Columbus, OH, United States;2. Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, United States;3. Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA, United States;4. Department of Orthopaedics, The Ohio State University, Columbus, OH, United States;5. School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH, United States;6. Center for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, OH, United States;1. School of Electronic Engineering, Jilin University, Changchun, Jilin, China;2. Department of Radiology, Provincial Hospital of Fujian Province, Teaching Hospital of Fujian Medical University, Fuzhou, China;3. Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA;4. School of Electronic Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 611731, China;1. Mayo Graduate School, Biomedical Engineering and Physiology Track, Mayo Clinic, Rochester, Minnesota, USA;2. Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA;3. Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA;1. Department of Medicine, Section of Cardiology, The University of Chicago, Chicago, IL, United States;2. Department of Surgery, Section of Cardiothoracic Surgery, The University of Chicago, Chicago, IL, United States;3. Department of Radiology, The University of Chicago, Chicago, IL, United States;4. Philips, Gainesville, FL, United States.;1. Department of Radiation Sciences, Umeå University, Umeå, Sweden;2. Department of Radiology, Uppsala University Hospital, Uppsala, Sweden;3. Applied Science Laboratory, GE Healthcare, Uppsala, Sweden |
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| Abstract: | The prevalence of cartilage lesions is much higher in football athletes than in the general population. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) has been shown to quantify regional variations of glycosaminoglycan (GAG) concentrations which is an indicator of early cartilage degeneration. The goal of this study is to determine whether dGEMRIC can be used to assess the influence in cartilage GAG concentration due to college level football play. Thirteen collegiate football players with one to four years of collegiate football play experience were recruited and both knee joints were scanned using a dedicated 8-channel phased array knee coil on a 3 T MRI system. The contrast concentrations within cartilage were calculated based on the T1 values from dGEMRIC scans. No substantial differences were found in the contrast concentrations between the pre- and post-season across all the cartilage compartments. One year collegiate football players presented an average contrast concentration at the pre-season of 0.116 ± 0.011 mM and post-season of 0.116 ± 0.011 mM. In players with multiple years of football play, contrast uptake was elevated to 0.141 ± 0.012 mM at the pre-season and 0.139 ± 0.012 mM at the post-season. The pre-season 0.023 ± 0.016 mM and post-season 0.025 ± 0.016 mM increase in contrast concentration within the group with multiple years of experience presented with a > 20% increase in contrast uptake. This may indicate the gradual, cumulative damage of football play to the articular cartilage over years, even though the effect may not be noticeable after a season of play. Playing collegiate football for a longer period of time may lead to cartilage microstructural alterations, which may be linked to early knee cartilage degeneration. |
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