Motion corrected DWI with integrated T2-mapping for simultaneous estimation of ADC,T2-relaxation and perfusion in prostate cancer |
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| Institution: | 1. Department of Radiation Sciences, Umeå University, Umeå, Sweden;2. Department of Radiology, Uppsala University Hospital, Uppsala, Sweden;3. Applied Science Laboratory, GE Healthcare, Uppsala, Sweden;1. Mayo Graduate School, Biomedical Engineering and Physiology Track, Mayo Clinic, Rochester, Minnesota, USA;2. Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA;3. Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA;1. Department of Medicine, Section of Cardiology, The University of Chicago, Chicago, IL, United States;2. Department of Surgery, Section of Cardiothoracic Surgery, The University of Chicago, Chicago, IL, United States;3. Department of Radiology, The University of Chicago, Chicago, IL, United States;4. Philips, Gainesville, FL, United States.;1. Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA;2. Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA;3. Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA;4. UCSF/UC Berkeley Joint Graduate Group in Bioengineering, San Francisco, CA, USA;5. Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA;1. Department of Radiology, Weill Cornell Medical College, New York, NY, United States;2. Department of Neurology, Weill Cornell Medical College, New York, NY, United States |
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| Abstract: | ObjectiveMultiparametric magnetic resonance imaging (MRI) and PI-RADS (Prostate Imaging – Reporting and Data System) has become the standard to determine a probability score for a lesion being a clinically significant prostate cancer. T2-weighted and diffusion-weighted imaging (DWI) are essential in PI-RADS, depending partly on visual assessment of signal intensity, while dynamic-contrast enhanced imaging is less important. To decrease inter-rater variability and further standardize image evaluation, complementary objective measures are in need.MethodsWe here demonstrate a sequence enabling simultaneous quantification of apparent diffusion coefficient (ADC) and T2-relaxation, as well as calculation of the perfusion fraction f from low b-value intravoxel incoherent motion data. Expandable wait pulses were added to a FOCUS DW SE-EPI sequence, allowing the effective echo time to change at run time. To calculate both ADC and f, b-values 200 s/mm2 and 600 s/mm2 were chosen, and for T2-estimation 6 echo times between 64.9 ms and 114.9 ms were used.ResultsThree patients with prostate cancer were examined and all had significantly decreased ADC and T2-values, while f was significantly increased in 2 of 3 tumors. T2 maps obtained in phantom measurements and in a healthy volunteer were compared to T2 maps from a SE sequence with consecutive scans, showing good agreement. In addition, a motion correction procedure was implemented to reduce the effects of prostate motion, which improved T2-estimation.ConclusionsThis sequence could potentially enable more objective tumor grading, and decrease the inter-rater variability in the PI-RADS classification. |
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