Static and dynamic liver stiffness: An ex vivo porcine liver study using MR elastography |
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| Affiliation: | 1. Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA;2. Department of Radiology, The Affiliated Hospital of Xuzhou Medical University, 99 West Huai-hai Road, Xuzhou, Jiangsu 221002, PR China;3. Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA;1. Changchun Institute of Applied Chemistry Chinese Academy of Sciences, No. 5625, Renmin Street, Changchun 130022, China;2. University of Chinese Academy of Sciences, No. 19, Yuquan Road 19, Beijing 100049, China;1. Division of Mathematical oncology, City of Hope National Medical Center, CA, USA;2. Department of Radiology and Imaging, Fortis Memorial Research Institute, Gurgaon, India;3. Department of Biostatistics and Health Informatics, SGPGIMS, Lucknow, India;4. Department of Neurosurgery, Fortis Memorial Research Institute, Gurgaon, India;5. SRL Diagnostics, Fortis Memorial Research Institute, Gurgaon, India;6. Philips Health System, Philips India Limited, Gurgaon, India;1. Institute of Clinical Physiology, National Council of Research, Pisa, Italy;2. Fondazione G. Monasterio CNR - Regione Toscana, Pisa, Italy;3. Laboratory of Medical Physics and Biotechnologies for Magnetic Resonance, IRCCS Stella Maris Foundation, Pisa, Italy;4. Imago7 Foundation, Pisa, Italy;1. Faculty of Engineering, Department of Electrical Engineering, University of Malaya, Kuala Lumpur, Malaysia;2. Department of Electrical Engineering, COMSATS Institute of Information Technology, Islamabad, Pakistan;3. Department of Computer Science & Engineering, Faculty of Science & Engineering, East West University, Dhaka 1212, Bangladesh;1. Department of Reparative Materials, Institute for Frontier Medical Sciences, Kyoto University, Japan;2. Department of Neurosurgery, Jikei University School of Medicine, Japan;3. Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Japan;4. Hiratsuka Technical Center, Tanaka Kikinzoku Kogyo K.K., Japan;5. Isehara Technical Center, Tanaka Kikinzoku Kogyo K.K., Japan |
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| Abstract: | Magnetic resonance elastography (MRE) is an MRI-based noninvasive technique for quantitatively assessing tissue stiffness. The hypothesis of this study is that stiffness increases with portal pressure. We further hypothesized that the rate of stiffness change with pressure would be larger in liver tissue treated to simulate the stiffening effects of fibrosis. In agreement with our hypothesis, the formalin-treated livers were stiffer than the untreated livers, and in both groups the liver stiffness increased with portal venous pressure. The rate of stiffness change with portal pressure was significantly greater after formalin treatment. In this study, we have developed an ex vivo liver model incorporating portal venous pressure variations and observed significant changes in liver stiffness due to portal pressure. This model could be useful for understanding and investigating the changes in the static and dynamic components of liver stiffness. |
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