Cancer recurrence monitoring using hyperpolarized [1-13C]pyruvate metabolic imaging in murine breast cancer model |
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| Institution: | 1. Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA, USA;2. The UC Berkeley - UCSF Graduate Program in Bioengineering, CA, USA;3. Biomedical Sciences Graduate Program, University of California at San Francisco, San Francisco, CA, USA;4. Department of Cell and Tissue Biology, University of California at San Francisco, San Francisco, CA, USA;1. Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA;2. Department of Radiology, The Affiliated Hospital of Xuzhou Medical University, 99 West Huai-hai Road, Xuzhou, Jiangsu 221002, PR China;3. Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA;1. Queensland University of Technology (QUT), Brisbane, Queensland, Australia;2. Institute of Health and Biomedical Innovation, Kelvin Grove, QLD 4059, Australia;1. Department of Radiology and BRIC, University of North Carolina at Chapel Hill, United States;2. Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, China;3. Department of Brain and Cognitive Engineering, Korea University, Seoul 02841, Republic of Korea;1. Beijing Key Laboratory for Biomaterials and Neural Regeneration, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China;2. State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;3. Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China;1. Faculty of Health Sciences, Hokkaido University, North- 12, West- 5, Kita- ku, Sapporo, Hokkaido 060-0812, Japan;2. Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, North- 15, West- 7, Kita- ku, Sapporo, Hokkaido 060-8638, Japan;3. C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center (LUMC), C3-Q, Albinusdreef 2, Leiden, 2333, ZA, The Netherlands;4. Department of Radiological Technology, Hokkaido University Hospital, North- 14, West- 5, Kita- ku, Sapporo, Hokkaido 060-8648, Japan |
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| Abstract: | The purpose of this work was to study the anatomic and metabolic changes that occur with tumor progression, regression and recurrence in a switchable MYC-driven murine breast cancer model. Serial 1H MRI and hyperpolarized 1-13C]pyruvate metabolic imaging were used to investigate the changes in tumor volume and glycolytic metabolism over time during the multistage tumorigenesis. We show that acute de-induction of MYC expression in established tumors results in rapid tumor regression and significantly reduced glycolytic metabolism as measured by pyruvate-to-lactate conversion. Moreover, cancer recurrences occurring at the tumor sites independently of MYC expression were observed to accompany markedly increased lactate production. |
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