Comparison of breath-hold,respiratory navigated and free-breathing MR elastography of the liver |
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| Institution: | 1. Dept of Radiology, University of Cambridge and Addenbrooke''s Hospital, Hills Rd, CB20QQ, England, United Kingdom;2. GE Healthcare, Amersham, HP7 9NA, United Kingdom;1. Department of Medical Imaging, Tongji Hospital, Tongji University, No. 389, Xincun Road, Putuo District, Shanghai 200065, China;2. Department of Medical Imaging, Renji Hospital, Medical School of Jiaotong University, No. 160, Pujian Road, Pudong District, Shanghai 200127, China;1. Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran;2. School of Cognitive Sciences, Institute for Research in Fundamental Sciences, 1954851167, Tehran, Iran;1. Department of Radiology, University of Cambridge, United Kingdom;2. GE Healthcare, Amersham, United Kingdom;3. GE Healthcare, Waukesha, WI, USA;4. Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, United Kingdom;1. Department of Biomedical Engineering, University of Alberta, Edmonton, Canada;2. Department of Physics, University of Alberta, Edmonton, Canada;3. Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Canada;1. Department of Radiology and Imaging Sciences, University of Utah, 729 Arapeen Drive, Salt Lake City, UT 84108, USA;2. Department of Bioengineering, University of Utah, 36 S Wasatch Drive, Rm 3100, Salt Lake City, UT 84112, USA;3. Siemens Medical Solutions, Inc., 660 First Avenue, 4th Floor, New York, NY 10016, USA;4. Siemens Medical Solutions, Inc., 729 Arapeen Drive, Salt Lake City, UT 84108, USA;5. Division of Nephrology, Department of Internal Medicine, University of Utah, 30 N 1900 E, Rm 4R312, Salt Lake City, UT 84132, USA |
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| Abstract: | PurposeHepatic magnetic resonance elastography (MRE) is currently a breath-hold imaging technique. Patients with chronic liver disease can have comorbidities that limit their ability to breath-hold (BH) for the required acquisition time. Our aim was to evaluate whether stiffness measurements obtained from a navigator-triggered MRE acquisition are comparable to standard expiratory breath-hold, inspiratory breath-hold or free-breathing in healthy participants.Materials and methodsTwelve healthy participants were imaged using the four methods on a clinical 1.5 T MR system equipped with a product MRE system. Mean liver stiffness, and measurable area of stiffness (with a confidence threshold >95%) were compared between sequences using the concordance correlation coefficient. Repeatability of each sequence between two acquisitions was also assessed.ResultsThe standard BH expiratory technique had high concordance with the navigated technique (r = 0.716), and low concordance with the BH inspiration (r = 0.165) and free-breathing (r = 0.105) techniques. The navigator-triggered technique showed no statistical difference in measurable area of liver or in repeatability compared with the standard expiratory acquisition (p = 0.997 and p = 0.407 respectively). The free-breathing technique produced less measurable liver area and was less repeatable than the alternative techniques. The increase in acquisition time for navigator techniques was 3 min 6 s compared to standard expiratory breath-hold.ConclusionNavigator-based hepatic MRE measurements are comparable to the reference standard expiratory breath-hold acquisition in healthy participants. |
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