Synthesis of optically active lipopeptide analogs from the outer membrane of Escherichia coli. |
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Authors: | M Kurimura M Takemoto K Achiwa |
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Affiliation: | School of Pharmaceutical Sciences, University of Shizuoka, Japan. |
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Abstract: | The synthesis of optically active lipopeptide derivatives has been accomplished by the use of chiral glycerol derivatives. Lipopeptide derivatives with (R)-glycerol moieties showed higher mitogenic activities than those with the (S)-configuration. N-2,2,2-Trichloroethoxycarbonyl lipopeptide derivatives increased mitogenic activity. |
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