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[Hmim]TFA catalyzed multicomponent reaction: direct,mild, and efficient procedure for the synthesis of 1,2-dihydroquinazoline derivatives
Authors:Minoo Dabiri   Mahboobeh Bahramnejad  Sahareh Bashiribod
Affiliation:1.Department of Chemistry, Faculty of Science,Shahid Beheshti University,Tehran,Iran;2.Department of Marine Biology, Faculty of Biological Sciences,Shahid Beheshti University,Tehran,Iran
Abstract:4-Substituted-spiro-1,2-dihydroquinazolines and related compounds were synthesized by direct reaction of 2-aminobenzophenones, isatin, or 1,2-diketone derivatives and ammonium acetate in the presence of dual role catalyst-solvent ionic liquid, [Hmim]TFA. Excellent conversion of starting materials was achieved to the desired 1,2-dihydroquinazoline products.
Keywords:
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