[Hmim]TFA catalyzed multicomponent reaction: direct,mild, and efficient procedure for the synthesis of 1,2-dihydroquinazoline derivatives |
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Authors: | Minoo Dabiri Mahboobeh Bahramnejad Sahareh Bashiribod |
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Affiliation: | 1.Department of Chemistry, Faculty of Science,Shahid Beheshti University,Tehran,Iran;2.Department of Marine Biology, Faculty of Biological Sciences,Shahid Beheshti University,Tehran,Iran |
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Abstract: | 4-Substituted-spiro-1,2-dihydroquinazolines and related compounds were synthesized by direct reaction of 2-aminobenzophenones, isatin, or 1,2-diketone derivatives and ammonium acetate in the presence of dual role catalyst-solvent ionic liquid, [Hmim]TFA. Excellent conversion of starting materials was achieved to the desired 1,2-dihydroquinazoline products. |
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