Bioactive metabolites of the marine actinobacterium Streptomyces sp. KMM 7210 |
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| Authors: | M. P. Sobolevskaya V. A. Denisenko A. S. Moiseenko L. S. Shevchenko N. I. Menzorova Yu. T. Sibirtsev N. Yu. Kim T. A. Kuznetsova |
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| Affiliation: | (1) Pacific Institute of Bioorganic Chemistry, Far-East Division of the Russian Academy of Sciences, 159 prosp. 100 Let Vladivostoku, 690022 Vladivostok, Russian Federation |
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| Abstract: | New 3-(4-hydroxybenzyl)piperazine-2,5-dione, together with the known N-[2-(4-hydroxy-phenyl)ethyl]acetamide (N-acetyltyramine), was isolated for the first time from the marine actinobacterium Streptomyces sp. The chemical structures of these compounds were determined by NMR spectroscopy and mass spectrometry. The cytotoxic activities of the compounds were estimated from their effects on sperm and eggs of the sea urchin Strongylocentrotus intermedius. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 807–809, April, 2007. |
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| Keywords: | marine actinobacteria Streptomyces sp piperazine-2,5-diones N-acetyl-tyramine biologically active substances |
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