A route to fluoroalkyl-substituted aromatic compounds involving fluoroalkylcopper intermediates |
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Authors: | V. C. R. Mcloughlin and J. Thrower |
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Affiliation: | Materials Department, Royal Aircraft Establishment, Farnborough, Hants U.K. |
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Abstract: | Interaction of iodofluoroalkanes, iodoaromatic compounds and copper in polar aprotic solvents at 110–130° leads to good yields of (fluoroalkyl)aromatic compounds. The iodofluoroalkanes and iodoaromatic compounds can bear a wide variety of substituents (carboxyl, nitro, amino, hydroxyl, etc). The reactions proceed via fluoroalkylcopper compounds which are markedly more stable than their non-fluorinated analogues. |
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