邻菲咯啉冠醚衍生物为载体的伯胺药物电极及机理研究

合成了邻菲咯啉-18-冠-6等四种含邻菲咯啉结构的冠醚化合物, 并用作载体制备伯胺电极, 以苄胺为模型化合物, 研究了电极特性, 并制备了测试美西律药物的选择性电极。研究了实验条件对电极性能的影响。用正交多项式回归法优化电极的膜组成。苄胺电极的线性范围1.0×10^-5~0.1mol/L, 斜率55.6mV/pc, 检测下限2.0×10^-6mol/L。美西律电极的线性范围6.0×10^-6~0.1mol/L, 检测下限8.0×10^-7mol, 斜率58.0mV/pc。同时研究了冠醚推动伯胺穿透大块液膜的传输行为。

Primary amine drug sensitive poly(vinyl chloride) membrane electrodes based on crown ether derivatives fo o-phenanthroline

Four crown ether derivatives of o-phenanthroline were synthesized and used as neutral carriers for preparing poly(vinyl chloride) (PVC) membrane electrodes sensing primary amine species. The potentiometric response characteristics of the electrodes prepared were investigated. The effect of experimental parameters on the electrode performance was studied. The membrane composition was optimized by using orthogonal polynomial regression. The electrode sensitive to benzyl amine as a model analyte showed a linear response range of 1.0 ?10-5 to 0.1 mol/L with a detection limit of 2.0 ?10-6 mol/L and a slope of 55.6 mV/decade. The linear potentiometric response of the mexiletine-sensitive electrode was 6.0 ?10-6 to 0.1 mol/L, and the detection limit was 8.0 ?10-7 mol/L with a slope of 58.0 mV/decade. The transfer behavior of amines and ammonium ions through an organic phase was investigated by means of the bulk liquid membrane transport experiment