| 以杯芳烃为基体的仿细胞色素P-450单加氧酶模型的合成 |
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| 引用本文： | 袁立华,陈淑华,赵华明,宁永成.以杯芳烃为基体的仿细胞色素P-450单加氧酶模型的合成[J].化学学报,1994,52(10):1035-1040. |
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| 作者姓名： | 袁立华 陈淑华 赵华明 宁永成 |
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| 作者单位： | 四川大学化学系;清华大学化学系 |
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| 摘 要： | 用对叔丁基杯4]芳烃与卟啉羧酸的酰氯化物反应,并引入金属,合成了杯芳烃-金属卟啉仿细胞色素P-450单加氧酶模型A,A及前体化合物6的结构经IR,^1H NMR,MS和元素分析确定,并确证A中杯环呈"锥体"构象
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| 关 键 词： | 红外分光光度法 元素分析 质谱法 质子磁共振谱法 细胞色素 杯芳烃 金属卟啉 P-450模型 |
Synthesis of a cytochrome P-450 monooxygenase model compound with calixarene residue |
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| YUAN LIHUA,CHEN SHUHUA,ZHAO HUAMING,NING YONGCHENG.Synthesis of a cytochrome P-450 monooxygenase model compound with calixarene residue[J].Acta Chimica Sinica,1994,52(10):1035-1040. |
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| Authors: | YUAN LIHUA CHEN SHUHUA ZHAO HUAMING NING YONGCHENG |
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| Abstract: | The cytochrome P 450 monooxygenase models I (Q = p-tolyl; M = Zn, MnCl, Co)(II) were prepared from reaction of p-tert-butylcalix4]arene with 5-p-(4-chlorocarbonylbutoxy)phenyl-10,15,20-tris(p-tolyl)porphyrin followed by inserting of metal ions. The structures of II and their precursor I (M = 2 H) (III) were confirmed by IR, 1H NMR, MS and elemental anal. 1H NMR (500MHz) spectra provide evidence for the "cone" conformation of calixarene residue in III. |
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| Keywords: | INFRARED SPECTROPHOTOMETRY ELEMENTAL ANALYSIS MASS SPECTROGRAPHY PROTON MAGNETIC RESONANCE SPECTROMETRY CYTOCHROME CALIXARENE METALLOPORPHYRIN |
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