Mixed-ligand complexes of gold(I) and silver(I) with heterocyclic thiones |
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Authors: | M Sakhawat Hussain M Latif Hossain Abderehman Al-Arfaj |
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Institution: | (1) Department of Chemistry King Fahd University of Petroleum and Minerals, KFUPM Box 1830, 31261 Dhahran, Saudi Arabia |
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Abstract: | Summary Novel mixed-ligand complexes of Ag1 and Au1 containing triphenylphosphine (TPP) and heterocyclic thiones, of general formula TPP–M–L]Cl and (TPP)2–M–L]Cl, where L=imidazolidine-2-thione (Imt), 1,3-diazinine-2-thione (Diaz) or N-isopropylimidazolidine-2-thione (iPrImt) have been prepared. The spectroscopic data are consistent with S-donation in all complexes. The magnitude of high-field shift in carbon-13 n.m.r. of the thioureide carbon on complexation is interpreted in terms of coordination geometry around the metal atoms. The mixed-ligand complexes are structurally similar to some of the commonly used antiarthritic Au1 drugs and are thus potentially useful in chemotherapy. |
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