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Synthesis of regiospecifically polysubstituted pyridazinones |
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| Authors: | Joã o X. de Araú jo-Jú nior,Martine Schmitt,Cyril Antheaume,Jean-Jacques Bourguignon |
| Affiliation: | a Institut Gilbert Laustriat, UMR 7175, 74 route du Rhin, BP 60024, 67401 Illkirch, France b Service Commun de RMN, Faculté de Pharmacie, 74 route du Rhin, BP 60024, 67401 Illkirch, France c Escola de Enfermagem e Farmacia, Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, cidade Universitaria, 57.072-970 Maceió-AL, Brazil |
| Abstract: | Desymmetrization of pyridazine-3,6-diones by the use of N-benzyl protective groups leads to useful starting materials for building polysubstituted pyridazine libraries in a regioselective manner. |
| Keywords: | N-Benzyl 4 (5)-substituted pyridazine 3,6-diones amination Palladium cross coupling reaction Microwave heating Suzuki Sonogashira |
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