A novel deacylation during the amination of trifluoromethyl β-dicarbonyl compounds |
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Authors: | Stefania Fioravanti Federico Ramadori |
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Institution: | Dipartimento di Chimica, Università degli Studi ‘La Sapienza’, P.le Aldo Moro 2, I-00185 Roma, Italy |
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Abstract: | Starting from trifluoromethyl β-dicarbonyl compounds, a rare loss of CF3CO was observed in the amination reactions performed under heterogeneous conditions using NsONHCO2Et as the aminating agent and CaO or NaH as the base, while corresponding nonfluorinated β-dicarbonyl compounds under analogous conditions give non deacylated aminated compounds. This reaction can facilitate a direct synthesis of N-substituted α-amino esters or α-amino ketones. |
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Keywords: | α-Amino esters α-Amino ketones Fluorinated compounds Deacylation |
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