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A novel deacylation during the amination of trifluoromethyl β-dicarbonyl compounds
Authors:Stefania Fioravanti  Federico Ramadori
Institution:Dipartimento di Chimica, Università degli Studi ‘La Sapienza’, P.le Aldo Moro 2, I-00185 Roma, Italy
Abstract:Starting from trifluoromethyl β-dicarbonyl compounds, a rare loss of CF3CO was observed in the amination reactions performed under heterogeneous conditions using NsONHCO2Et as the aminating agent and CaO or NaH as the base, while corresponding nonfluorinated β-dicarbonyl compounds under analogous conditions give non deacylated aminated compounds. This reaction can facilitate a direct synthesis of N-substituted α-amino esters or α-amino ketones.
Keywords:α-Amino esters  α-Amino ketones  Fluorinated compounds  Deacylation
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