Effets electroniques en stereochimie—III : Réduction asymétrique de phénylalkylcétones diversement substituées par des organomagnésiens aromatiques chiraux |
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| Authors: | Joël Capillon Jean-Paul Guétté |
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| Institution: | Laboratoire de Chimie Organique, Conservatoire National des Arts et Métiers, 292 rue Saint-Martin, 75141 Paris Cedex 03, France |
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| Abstract: | The asymmetric reduction of phenylalkylketones p-X-C6H4COR (X = H, R = C2H5, 1C3H7, 1C4H9 and R = C2H5, X = CH3, OCH3, Cl, CF3) with chiral aromatic Grignard reagents p-YC6H4-CH(C2H5) CH2MgCl (Y = H, OCH3, CF3) give optically active phenylalkylcarbinols. The absolute configuration and the enantiomeric excess depends on electronic effects of substituents carried by the organomagnesium reagent and/or ketone. |
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