Preparation of unsymmetrical disulfides by using sulfines1 |
| |
Authors: | Binne Zwanenburg Piotr KieŁbasiński |
| |
Affiliation: | Department of Organic Chemistry, University of Nijmegen, Toernooiveld, Nijmegen, The Netherlands |
| |
Abstract: | Acidolytic cleavage of unsymmetrically substituted dithioacetal monoxides, ArCH(SR)S(O)Me has been used to prepare linear unsymmetrical disulfides RSSMe. Disproportionation was suppressed by the addition of a small amount of benzyl mercaptan. The required starting materials were conveniently obtained from appropriately substituted sulfines ArC(=SO)SR and methyl lithium. The following disulfides were prepared: R =n-C4H9 (73.5%), n-C7H15 (78%), Ph (77.3%), AcO(CH2)10 (81.5%).The unsymmetrical dithioacetal PhCH(SEt)SC7H15-n gave upon oxidation with one equivalent of peracid a mixture of two dithioacetal monoxides which on treatment with HClO4 led to three disulfides. This result is discussed in term of the mechanism of acidolysis. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|