Modular NRPSs are monomeric |
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| Authors: | Smith Stuart |
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| Affiliation: | Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609, USA. |
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| Abstract: | NRPSs, PKSs, and hybrid NRPS/PKSs are modular proteins with similar assembly-line organizations. Although PKSs function as dimers, new data demonstrate that functional NRPSs are monomeric. This discovery has significant implications for engineering artificial assemblies for the production of novel biotherapeutics. |
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