An efficient 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU)-mediated synthesis of 5-(trifluoromethyl)-N-alkyl-1-(3-phenylisoquinoline-1-yl)-1H-pyrazole-4-carboxamides |
| |
| Authors: | K Prabakaran F Nawaz Khan Jong Sung Jin |
| |
| Institution: | 1. Organic and Medicinal Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, 632 014, Tamil Nadu, India
2. Division of High Technology Materials Research, Busan Center, Korea Basic Science Institute (KBSI), Busan, 618 230, Korea
|
| |
| Abstract: | A series of 5-(trifluoromethyl)-N-alkyl-1-(3-phenylisoquinoline-1-yl)-1H-pyrazole-4-carboxamides 4 has been effectively achieved in high yield and purity from the reaction of pyrazole carboxylic acid 2 with amines 3 in the presence of TBTU as a catalyst and diisopropyl ethylamine as a base in acetonitrile at room temperature. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
