| 1-氨甲基-6,7-二甲氧基-1,2,3,4-四氢异喹啉盐酸盐的合成及表征 |
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| 引用本文： | 程训官,夏铸,郑小红,余瑜.1-氨甲基-6,7-二甲氧基-1,2,3,4-四氢异喹啉盐酸盐的合成及表征[J].光谱实验室,2011,28(5):2198-2201. |
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| 作者姓名： | 程训官 夏铸 郑小红 余瑜 |
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| 作者单位： | 重庆医科大学药学院 重庆市渝中区医学院路1号400016 |
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| 基金项目： | 国家自然科学基金资助项目(30772595,30171070和30371632); 重庆市科委攻关资助项目(20021425); 重庆市教委资助项目(20021804) |
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| 摘 要： | 以3,4-二甲氧基苯乙胺为原料,经氯乙酰氯酰化得到N-氯乙酰基-3,4-二甲氧基苯乙胺,通过与邻苯二甲酰亚胺钾烃化,在P2O5的作用下经Bischler-Napieralski环合后,用水合肼肼解,硼氢化钾还原后与盐酸作用得1-氨甲基-6,7-二甲氧基-1,2,3,4-四氢异喹啉盐酸盐。产品结构经IR、1H NMR、MS确证。
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| 关 键 词： | 四氢异喹啉 环合 还原 结构表征 |
Synthesis and Characterization of 1-Aminomethyl-6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline Hydrochloride |
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| CHENG Xun-Guan,XIA Zhu,ZHENG Xiao-Hong,YU Yu.Synthesis and Characterization of 1-Aminomethyl-6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline Hydrochloride[J].Chinese Journal of Spectroscopy Laboratory,2011,28(5):2198-2201. |
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| Authors: | CHENG Xun-Guan XIA Zhu ZHENG Xiao-Hong YU Yu |
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| Institution: | CHENG Xun-Guan XIA Zhu ZHENG Xiao-Hong YU Yu(School of Pharmacy,Chongqing Medical University,Chongqing 400016,P.R.China) |
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| Abstract: | 1-aminomethyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride was synthesized from 3,4-dimethoxy-phenethylamin and chloroacetyl chloride via acylation,alkylation with phthalimide potassium,Bischler-Napieralski cyclization with the effect of P2O5,hydrazinolysis with hydrazine hydrate,reduction with potassium borohydride,reaction with HCl.The structures of target compound were characterized by IR,1H NMR and MS. |
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| Keywords: | Tetrahydroisoquinoline Cyclization Reduction Structure Characterization |
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