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| HPLC测定盐酸二甲双胍肠溶片的含量 | |
| 引用本文： | 李艺,陈峰杰,张良珂,赵春景,张景勍.HPLC测定盐酸二甲双胍肠溶片的含量[J].光谱实验室,2011,28(6):3235-3238. |
| 作者姓名： | 李艺 陈峰杰 张良珂 赵春景 张景勍 |
| 作者单位： | 1. 重庆医科大学药物高校工程研究中心和生物化学与分子药理学重点实验室 重庆市渝中区医学院路1号400016 2. 重庆医科大学附属第一医院药剂科 重庆市渝中区友谊路1号400016 3. 重庆医科大学附属第二医院药剂科 重庆市渝中区临江路74号400010 |
| 摘 要： | 建立高效液相色谱法测定盐酸二甲双胍肠溶片含量的方法.采用Hypersil ODS2色谱柱(4.6mm×250mm,5μm),0.05％庚烷磺酸钠溶液(用10％磷酸溶液调节pH值至4.0)∶乙腈(84∶16)为流动相,紫外检测波长233nm;流速1.0mL/min;柱温为30℃.盐酸二甲双胍在0.11-10.70μg/m... |
| 关 键 词： | 高效液相色谱法 盐酸二甲双胍 肠溶片 |
Determination of Metformin Hydrochloride in Metformin Hydrochloride Enteric-Coated Tablets by HPLC |
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| LI Yi,CHEN Feng-Jie,ZHANG Liang-Ke,ZHAO Chun-Jing,ZHANG Jing-Qing.Determination of Metformin Hydrochloride in Metformin Hydrochloride Enteric-Coated Tablets by HPLC[J].Chinese Journal of Spectroscopy Laboratory,2011,28(6):3235-3238. | |
| Authors: | LI Yi CHEN Feng-Jie ZHANG Liang-Ke ZHAO Chun-Jing ZHANG Jing-Qing |
| Institution: | LI Yi CHEN Feng-Jiea ZHANG Liang-Ke ZHAO Chun-Jingb ZHANG Jing-Qing(Medicine Engineering Research Center,Chongqing Key Laboratory of Biochemical & Molecular Pharmacology,Chongqing Medical University,Chongqing 400016,P.R.China)a(Department of Pharmacy,The First Affiliated Hospital Chongqing Medical University,P.R.China)b(Department of Pharmacy,The Second Affiliated Hospital Chongqing Medical University,Chongqing 400010,P.R.China) |
| Abstract: | The method for the determination of metformin hydrochloride in metformin hydrochloride enteric-coated tablets was established by HPLC.Samples were separated on Hypersil ODS2 column（4.6mm×250mm,5μm）with 0.05% heptane-1-sulfonic acid sodium salt solution（pH was adjusted to 4.0 by 10% phosphoric acid）-acetonitrile（84∶16） as the mobile phase at a flow rate of 1.0mL/min.The detection wavelength was 233nm,and the column temperature was 30℃.The linear range of metformin hydrochloride was 0.11—10.70μg/mL（r=0.9997） with an average recovery of 99.22%（RSD=1.79%）.The method is simple,accurate,and materials in the preparation has no interference and suitable for the determination of main content in metformin hydrochloride enteric-coated tablets. |
| Keywords: | HPLC Metformin Hydrochloride Enteric-Coated Tablets |
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