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| 高效液相色谱法测定普卢利沙星胶囊的含量 | |
| 引用本文： | 刘霞,李伟,范小娜,糜志远.高效液相色谱法测定普卢利沙星胶囊的含量[J].光谱实验室,2011,28(5):2643-2645. |
| 作者姓名： | 刘霞 李伟 范小娜 糜志远 |
| 作者单位： | 1. 赣南医学院江西天然药物研究与开发重点实验室 江西省赣州市医学院路1号341000 2. 赣南医学院康复学院 江西省赣州市341000 3. 湖北荷普药业有限公司 武汉市430037 |
| 摘 要： | 建立高效液相色谱法测定普卢利沙星胶囊含量的方法。采用高效液相色谱法,以0.01mol.L-1盐酸溶液为溶剂,测定波长为280nm。在10—100μg.mL-1浓度范围内,主峰面积与相应的浓度呈良好的线性关系（r=0.9998）。重复测定峰面积平均值为1215.9（n=6）,相对标准偏差为0.7%。平均回收率为99.77%（n=9）,相对标准偏差为0.26%。该方法准确简便、重复性好,可作为普卢利沙星胶囊含量测定的有效方法。 |
| 关 键 词： | 普卢利沙星胶囊 含量 高效液相色谱法 |
Determination of Prulifloxacin Capsules by HPLC |
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| LIU Xia,LI Wei,FAN Xiao-Na,MI Zhi-Yuan.Determination of Prulifloxacin Capsules by HPLC[J].Chinese Journal of Spectroscopy Laboratory,2011,28(5):2643-2645. | |
| Authors: | LIU Xia LI Wei FAN Xiao-Na MI Zhi-Yuan |
| Institution: | LIU Xia LI Weia FAN Xiao-Na MI Zhi-Yuanb(Jiangxi Key Lab for Research and Development of Natural Drug,Gannan Medical University,Ganzhou,Jiangxi 341000,P.R.China)a(Rehabilitation Institute of Gannan Medical University,P.R.China)b(Hope Pharmaceutical Group Co.,Ltd.,Wuhan 430037,P.R.China) |
| Abstract: | The method for the determination of the content of prulifloxacin capsules was established by HPLC,with 0.01mol·L-1 HCl as solvent,and the detection wavelength was at 280nm.There was a quite good linear relationship between main peak area and the concentrations（r=0.9998） in the range of 10—100μg·mL-1.The main peak area was 1215.9 and RSD was 0.7%（n=6）.The average recovery was 99.77%（n=9）,and the RSD was 0.26%.The method is simple,accurate,reliable and suitable for the determination of the content of prulifloxacin capsules. |
| Keywords: | Prulifloxacin Capsules Content HPLC |
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