| 解毒活血滋阴方对系统性红斑狼疮患者血清Blys、IL-10的影响 |
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| 引用本文： | 卞华,吕芹,黄显章,陈志国.解毒活血滋阴方对系统性红斑狼疮患者血清Blys、IL-10的影响[J].南阳理工学院学报,2010,2(6). |
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| 作者姓名： | 卞华 吕芹 黄显章 陈志国 |
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| 作者单位： | 1. 南阳理工学院张仲景国医学院,河南,南阳,473004
2. 南阳医学高等专科学校,河南,南阳,473061 |
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| 摘 要： | 本文旨在探讨解毒活血滋阴方对系统性红斑狼疮(SLE)患者血清B淋巴细胞刺激因子(Blys)、IL-10的影响。将65例SLE患者随机分为2组:西医组(32例)采用强的松、甲氨蝶呤、羟氯喹治疗;中西医结合组(33例)采用解毒活血滋阴方联合强的松、甲氨蝶呤、羟氯喹治疗,均治疗3个月。运用酶联免疫吸附试验(ELISA)法检测血清Blys、IL-10的含量。结果显示,与治疗前相比,西医组、中西医结合组血清Blys、IL-10含量均明显降低(P<0·01),且中西医结合组Blys、IL-10的改善更加明显(P<0.05,P<0.01)。同时,西医组、中西医结合组均能明显降低SLE患者系统性红斑狼疮狼疮活动指数(SLEDAI)积分(P<0.01),且中西医结合组SLEDAI积分的改善更加明显(P<0.05)。结论:解毒活血滋阴方能明显降低SLE患者血清Blys、IL-10的含量,这可能是其作用机制之一。
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| 关 键 词： | 解毒活血滋阴方 系统性红斑狼疮 B淋巴细胞刺激因子 IL-10 |
EFFECT OF JIEDU HUOXUE ZIYIN RECIPE ON LEVELS OF SERUM B LYMPHOCYTE STIMULATOR AND INTERLEUKIN-10 IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS |
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| BIAN Hua,LV Qin,HUANG Xian-zhang,CHEN Zhi-guo.EFFECT OF JIEDU HUOXUE ZIYIN RECIPE ON LEVELS OF SERUM B LYMPHOCYTE STIMULATOR AND INTERLEUKIN-10 IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS[J].Journal of Nanyang Institute of Technology,2010,2(6). |
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| Authors: | BIAN Hua LV Qin HUANG Xian-zhang CHEN Zhi-guo |
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| Institution: | 1(1.Zhang Zhongjing Traditional Chinese Medicine College; Nanyang 473004; China; 2.Nanyang Medical College; Nanyang 473061; China); |
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| Abstract: | The effect of Jiedu Huoxue Ziyin Recipe (JDHXZYR) on levels of serum B lymphocyte stimulator (Blys)and interleukin-10 in patients with systemic lupus erythematosus was studied in this paper. Sixty-five mild to moderate patients with SLE were randomized into two groups. Western medicine group(32cases) were treated with prednisone, methotrexate and hydroxychloroquine. Integrated Chinese and western medicine group (33cases) were treated with JDHXZYR combined with prednisone, methotrexate and hydroxychloroquine... |
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| Keywords: | Jiedu Huoxue Ziyin Recipe systemic lupus erythematosus B lymphocyte stimulator Interleukin 10 |
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